Covalent small molecule drug discovery platform

Avila developed a novel chemistry approach ‘Avilomics’ to discover oral small molecule covalent inhibitors of proteases and kinases. Avilomics allows the design of highly specific compounds that irreversibly bind to the protein target to improve therapeutic index and clinical efficacy.

Avila’s most advanced product candidate, AVL-292, a highly selective Btk inhibitor was in Phase I clinical development at the time of its acquisition by Celgene.

CEO  Katrine Bosley

Advent Contact  Raj Parekh

Advent invested in the Series A in 2007. Avila was acquired by Celgene in 2012 for $925m in cash and milestones.
Exited Investments
26 January 2012 in Avila, Press Release

Celgene to Acquire Avila Therapeutics

Press Release.   Oral Btk inhibitor AVL-292 offers promising potential for treatment of B-cell diseases Avilomics™ Platform enhances drug discovery capabilities SUMMIT, NJ and BEDFORD, MA – January 26, 2012…
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20 January 2012 in Avila, Press Release

Avila Announces FDA Allowance of Partner Clovis Oncology’s IND Application

Press Release.   Avila Announces FDA Allowance of Partner Clovis Oncology’s IND Application for CO-1686, an Oral EGFR Mutant-Selective Inhibitor Triggers $4 Million Milestone Payment to Avila BEDFORD, Mass.--(BUSINESS WIRE)--…
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8 June 2011 in Avila, Press Release

Avila Therapeutics agreement with NIAID

Press Release.   WALTHAM, MA – June 8, 2011 –Avila Therapeutics, Inc. a biotechnology company developing targeted covalent drugs that treat diseases through protein silencing, announced that it has entered…
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2 November 2010 in Avila, Press Release

Avila Presents New Data on its Novel, Orally-Available Targeted Covalent Drug, AVL-192

Press Release.   Covalent Inhibition Achieves Superior Potency Against Drug-Resistant HCV Mutants   BOSTON and WALTHAM, MA – Avila Therapeutics™, Inc., a biotechnology company developing novel targeted covalent drugs, presented…
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