Covalent small molecule drug discovery platform
Avila developed a novel chemistry approach ‘Avilomics’ to discover oral small molecule covalent inhibitors of proteases and kinases. Avilomics allows the design of highly specific compounds that irreversibly bind to the protein target to improve therapeutic index and clinical efficacy.
Avila’s most advanced product candidate, AVL-292, a highly selective Btk inhibitor was in Phase I clinical development at the time of its acquisition by Celgene.
CEO Katrine Bosley
Advent invested in the Series A in 2007. Avila was acquired by Celgene in 2012 for $925m in cash and milestones.
Celgene to Acquire Avila Therapeutics
Press Release. Oral Btk inhibitor AVL-292 offers promising potential for treatment of B-cell diseases Avilomics™ Platform enhances drug discovery capabilities SUMMIT, NJ and BEDFORD, MA – January 26, 2012…Read More
Avila Announces FDA Allowance of Partner Clovis Oncology’s IND Application
Press Release. Avila Announces FDA Allowance of Partner Clovis Oncology’s IND Application for CO-1686, an Oral EGFR Mutant-Selective Inhibitor Triggers $4 Million Milestone Payment to Avila BEDFORD, Mass.--(BUSINESS WIRE)--…Read More
Avila Therapeutics agreement with NIAID
Press Release. WALTHAM, MA – June 8, 2011 –Avila Therapeutics, Inc. a biotechnology company developing targeted covalent drugs that treat diseases through protein silencing, announced that it has entered…Read More
Avila Presents New Data on its Novel, Orally-Available Targeted Covalent Drug, AVL-192
Press Release. Covalent Inhibition Achieves Superior Potency Against Drug-Resistant HCV Mutants BOSTON and WALTHAM, MA – Avila Therapeutics™, Inc., a biotechnology company developing novel targeted covalent drugs, presented…Read More