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Advent Life Sciences

Advent Life Sciences Announces Appointment of Alan Walts as Venture Partner

By Advent Life Sciences, Press Release
Press Release.

 

9th January 2014, London: – Advent Life Sciences announced today the appointment of Alan Walts as a Venture Partner.  Alan brings 27 years of biotech industry experience in corporate venture capital, business development, research and development, and general management at Genzyme Corporation.  He most recently managed Genzyme’s corporate venture fund, Genzyme Ventures (now Sanofi-Genzyme BioVentures), where he was responsible for identifying and managing a portfolio of investments.

Alan earlier led business and corporate development activities in Genzyme’s Therapeutics business, where he initiated and executed a number of transactions and new business initiatives that led to several innovative marketed products.  Alan’s roles at Genzyme also included President of Genzyme Pharmaceuticals and head of chemistry and biopolymer research.

Alan received a Ph.D. in chemistry from MIT in 1985, carried out post-doctoral research in biochemistry at MIT with Professor Christopher Walsh, and completed the executive Program for Management Development at Harvard Business School in 1993.

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About Advent Life Sciences:
Advent Life Sciences is the dedicated Life Sciences team at Advent Venture Partners, one of Europe’s best established venture capital firms.  Advent Life Sciences predominantly founds and invests in early-stage life sciences companies in the UK, Europe and the US, that have a first- or best-in-class approach. Recent investments include:  UniQure (formerly AMT), a company that recently obtained the first EMA approval for a gene therapy product; EUSA Pharma, a speciality pharmaceutical company that obtained a BLA approval for its lead product Erwinase® and was subsequently acquired by Jazz Pharmaceuticals; Algeta (OSE: ALGETA), an oncology company that obtained FDA and EMA approval for Xofigo®, a treatment for bone metastases and disseminated tumours; Avila Therapeutics, a biotechnology company developing targeted covalent drugs acquired by Celgene; and CN Creative Ltd, a medical device company acquired by BAT.

For more information, please contact:

Melanie McIntosh
Advent Life Sciences
Phone: +44 (0) 20 7932 2100
Email: melanie.mcintosh@adventventures.com
www.adventventures.com

Advent Life Sciences Announces Appointment of Ian Nicholson as Operating Partner

By Advent Life Sciences, Press Release
Press Release.

 

17th December 2012, London: – Advent Life Sciences announced today the appointment of Ian Nicholson as an Operating Partner.  Ian brings over 20 years of international experience in management, licensing, mergers and acquisitions in the life sciences sector.  He was most recently CEO of Chroma Therapeutics Ltd, prior to which he held senior positions at Celltech Group plc, Oxford Asymmetry, Lonza AG and Amersham International plc. Ian has served on the Boards of several Public and Private Companies in the UK and Europe.  Ian holds a BSc (Hons) from University College London and an MBA from Boston University.

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About Advent Life Sciences:
Advent Life Sciences is the dedicated Life Sciences team at Advent Venture Partners, one of Europe’s best established growth and venture capital firms.  Advent Life Sciences invests predominantly in early-stage and growth equity life sciences companies in the UK, Europe and the US.  It will back companies that have a first- or best-in-class approach in a range of sectors within the life sciences sector, including new drug discovery, enabling technologies, med-tech and diagnostics.

Advent Life Sciences is a leader in European life sciences venture capital.  Its investments include:  PowderMed, a therapeutic DNA vaccine company sold to Pfizer; Thiakis, an obesity treatment company acquired by Wyeth Pharmaceuticals; Respivert, a drug discovery company focused on respiratory diseases that was acquired by Johnson & Johnson; EUSA Pharma, a transatlantic speciality pharmaceutical company acquired by Jazz Pharmaceuticals; Avila Therapeutics, a biotechnology company developing targeted covalent drugs acquired by Celgene Corporation, Micromet, a biotechnology company acquired by Amgen and Algeta (OSE: ALGETA), an oncology company developing treatments for bone metastases and disseminated tumours.

For more information, please contact:

Raj Parekh
Advent Life Sciences
Ph: +44 (0) 20 7932 2100
Email: raj.parekh@adventventures.com

www.adventventures.com

Advent Life Sciences Fund I Receives Additional Investments

By Advent Life Sciences, Press Release
Press Release.

 

Final Fund Size of £101.3 Million ($158 Million)

10th July 2012, London:  Advent Life Sciences today announced an investment into its Life Sciences Fund I from a new institutional investor, and increased commitments from certain existing LPs. This brings the Fund to an aggregate amount of £101.3m (€128m, US$158m). The Fund, which closed in November 2010, was re-opened to accept the new and increased commitments.  Advent Life Sciences Fund I is dedicated largely to early stage UK and European Life Sciences Venture companies.

Raj Parekh, General Partner, commented

“We appreciate the strong support from our new and existing LPs.  Advent Life Sciences Fund I has been raised almost entirely from independent financial investors, despite the difficult fundraising environment.  The Fund has now exceeded our initial target.”

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About Advent Life Sciences:
Advent Life Sciences is the dedicated Life Sciences team at Advent Venture Partners, one of Europe’s best established growth and venture capital firms.  Advent Life Sciences invests predominantly in early-stage and growth equity life sciences companies in the UK, Europe and the US.  It will back companies that have a first- or best-in-class approach in a range of sectors within the life sciences, including new drug discovery, enabling technologies, med-tech and diagnostics.

Advent Life Sciences is a leader in European life sciences venture capital.  Its investments include:  PowderMed, a therapeutic DNA vaccine company sold to Pfizer; Thiakis, an obesity treatment company acquired by Wyeth Pharmaceuticals; Respivert, a drug discovery company focused on respiratory diseases that was acquired by Johnson & Johnson; EUSA Pharma, a transatlantic speciality pharmaceutical company acquired by Jazz Pharmaceuticals; Avila Therapeutics, a biotechnology company developing targeted covalent drugs acquired by Celgene Corporation, Micromet, a biotechnology company acquired by Amgen and Algeta (OSE: ALGETA), an oncology company developing treatments for bone metastases and disseminated tumours.

www.adventventures.com

For more information contact:

Advent Venture Partners (London)
Josephine Defty
Ph: +44 (0) 20 7932 2116
Email: Josephine@adventventures.com

Advent Life Sciences Announces Appointment of Alain Huriez as Venture Partner

By Advent Life Sciences, Press Release
Press Release.

 

27th June 2012, London: – Advent Life Sciences announced today the appointment of Alain Huriez MD, as a Venture Partner.   Alain brings 22 years of experience in management, drug development and financing in the life sciences sector, including as CEO of TcLand Expression and Neovacs, Associate Partner at Truffle Capital and Vice President at Quintiles.   Prior to this, he was a practising physician.   Alain has also been responsible for several initiatives in Europe within the areas of personalised medicine, biomarkers and high value diagnostics through his work as chairman of EPEMED, the European Personalised Medicine Association.

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About Advent Life Sciences:
Advent Life Sciences is the dedicated Life Sciences team at Advent Venture Partners, one of Europe’s best established growth and venture capital firms.  Advent Life Sciences invests predominantly in early-stage and growth equity life sciences companies in the UK, Europe and the US.  It will back companies that have a first- or best-in-class approach in a range of sectors within the life sciences, including new drug discovery, enabling technologies, med-tech and diagnostics.

Advent Life Sciences is a leader in European life sciences venture capital.  Its investments include:  PowderMed, a therapeutic DNA vaccine company sold to Pfizer; Thiakis, an obesity treatment company acquired by Wyeth Pharmaceuticals; Respivert, a drug discovery company focused on respiratory diseases that was acquired by Johnson & Johnson; EUSA Pharma, a transatlantic speciality pharmaceutical company acquired by Jazz Pharmaceuticals; Avila Therapeutics, a biotechnology company developing targeted covalent drugs acquired by Celgene Corporation, Micromet, a biotechnology company acquired by Amgen and Algeta (OSE: ALGETA), an oncology company developing treatments for bone metastases and disseminated tumours.

For more information contact:

Advent Venture Partners
Josephine Defty
Ph: +44 (0) 20 7932 2116
Email: Josephine@adventventures.com

Need a light? It’s okay, I’ll just plug it in

By Advent Life Sciences, CN Creative, Press Release
Press Release.

 

Louise Hodgetts has struggled to overcome her 30-a-day habit.  A smoker for two decades, she worries about her family’s history of cancer, but nicotine patches and gum failed to free her from the addiction.

Now, the 34-year-old is trying something new- an electronic E-cigarette.

So far, so good.  With the help of the 3in-long piece of plastic she hasn’t smoked the real thing for a month, feels better for it, and has bought a television with the money saved.

“Its working- and I’ve recommended it to my brother,”

said Hodgetts, from Bracknell, Berkshire.

Substitute cigarettes are not new, but the market is beginning to boom.  And tobacco companies are ready to plough substantial sums into finding the next gadget to supply smokers with a guilt-free kick.

With the market for tobacco in relentless decline in the West, cashing in on those who want to quit is the obvious source of growth.

Imperial Tobacco, maker of brands such as Davidoff and Lambert & Butler, has recently done a secret deal to invest in one business that believes it may have the magic formula.

In April, Lorillard, the American company behind Newport cigarettes, bought Blu e-cigarettes for $135m ( £87m).  Japan Tobacco International, owner of Benson & Hedges, has a minority stake in Ploom, another manufacturer, and is working on plans to commercialise the devices globally.

Philip Morris International, the world’s biggest listed tobacco company, is working on a next- generation version of the technology, while British American Tobacco has set up a subsidiary to target the market.

There is good reason for the rush of activity.

“The growth of e-cigarettes has been unbelievable, particularly in the past 12 months,”

said Damien Scott of Skycig, an e-cigarette brand owned by Gibraltar-based Zeus Ventures.

“I don’t think it will stop any time soon.”

Sales of e-cigarettes in America, where there are more than 100 brands, are likely to double this year to $500m, according to analysts at UBS, the investment bank. That is tiny compared with the tobacco market-Americans spent $88 billion on cigarettes last year-yet the growth prospects are enough to lure investors into “non-tobacco nicotine delivery devices”.

Britain is expected to follow the same pattern as America.

An estimated 21% of adults smoke, of whom three-quarters have tried to quit. Businesses and investors backing the new technology hope that it will appeal to those millions-and provide a new source of revenue.  Critics claim the devices simply replace one addiction with another, albeit less harmful without the tar and other damaging substances.

Strikingly, the growth of e-cigarettes does not appear to have hit sales of nicotine patches and gum.  Glaxo Smith Kline, maker of Nicorette, saw worldwide sales of its range grow 3% in the first quarter of this year.  But, with smokers forced out of public places onto the streets for a puff, the new aids are catching on fast.

Most of the market is based on the battery-powered cigarette developed by a Chinese pharmacist in 2003.  These rechargeable devices heat up a cartridge of nicotine in water, releasing vapour to be inhaled.  To date, they have not been hampered by the strict controls placed on medical devices and real cigarettes, but many in the industry expect this to change.

Venture capital firms have also been vying for a piece of the burgeoning market.  In January, Britain’s Advent Life Sciences led a £2m fundraising for CN Creative, which is developing a new type of “smoking cessation device”.

Across the Atlantic, Catterton Partners,which has backed businesses such as Kettle crisps, has invested $20m in Njoy, an American e-cigarette manufacturer.

Two young British entrepreneurs are among those aiming to produce the next generation of cigarette substitutes.

Alex Hearne is the founder of Kind Consumer, which has received investment from business figures such as Sir Terry Leahy, former boss of Tesco, Jon Moulton, the venture capitalist, and Sir Peter Davis, previously head of Prudential.

An asthma sufferer as a child, with parents who smoked, Hearn had good reason to develop a device to help reduce tobacco consumption.

After spending a decade on research, producing more than 700 prototypes, Kind Consumer hopes to apply for approval from the Medicines and Health-care Products Regulatory Agency within 12 months.

“We strongly believe that these devices should be regulated.  The public should know what they are buying,” said Hearn, 29.

His design is not electronic but a kind of cigarette-shaped aerosol that delivers a burst of nicotine through a breath-operated valve.  A battery is not needed.

The device, as yet unnamed, will be sold like cigarettes in a pack, with each one thrown away when the nicotine has been exhausted.

With the battery-powered e-cigarettes, users by one device and then replacement nicotine cartridges as needed.  Hearn said, “No substitute is going to be exactly the same [as a cigarette], but we wanted to try to make our device as close as possible to the experience of smoking.”

His company has received backing from British American Tobacco, the second biggest cigarette maker outside china.  Its Nicoventures subsidiary is funding development and will be the distributor.

Another Briton hoping to crack the market is David Newns, 27, who co-founded CN Creative in 2008.  The company already sells an electronic cigarette, the Intellicig, but is also working towards producing an inhaler under the name Nicadex.  It, too, hopes to receive approval from Health Watchdogs in Britain, Europe and America and will begin the application process towards the end of the year.

That will be one more smoke-free competitor for the tobacco companies, many of which are reluctant to reveal much about there plans to enter the new market.

Bristol –based Imperial Tobacco is the latest of the giants to become involved.  The company admitted it had made “a very small investment” in an e-cigarette business, but refuse to disclose the details beyond saying that the investment did not involve taking an equity stake.

Imperial said the arrangement was designed simply to “build knowledge and expertise in the area”.

The importance of the involvement of the big names should not be underestimated, though. Newns said: “In the past they have said that cigarettes are their business.  For the first time, they are opening their eyes to other innovations, Its very encouraging.”

Cashing in on those who want to stop is the obvious source of growth.

For more information on CN Creative please visit their website here

Advent Life Sciences Invests in Acutus Medical and Acutus Medical Expands Senior Management Team

By Advent Life Sciences, Press Release
Press Release.

 

20th January 2012, London: – Advent Life Sciences announced it has invested $2.2 million in Acutus Medical, a medical technology company based in San Diego and Zurich, as part of a Series A of $5.4 million which includes previously announced participation by Index Ventures and the company founders.  Acutus is developing an electrophysiological mapping system to optimize the treatment of cardiac arrhythmias and will use the initial funding to develop prototypes of its novel system.

Acutus Medical, founded in 2011, is developing technology to allow significantly improved mapping of the cardiac space. This will enable instantaneous and precise visualization of areas of the heart to be ablated in patients with cardiac arrhythmias such as atrial fibrillation and ventricular tachycardia. The advanced technology is being developed in the US and Europe. The Acutus system is being designed to provide unprecedented accuracy for the real-time guidance necessary to determine the location for ablating sources of arrhythmias.

Shahzad Malik, general partner at Advent Life Sciences and new Board member at Acutus Medical, said,

“We are delighted to invest in Acutus Medical and this investment underlines our commitment to investing in first-in-class and best-in-class life sciences opportunities.  The treatment of atrial fibrillation using medical devices is an area with substantial growth potential and we believe Acutus has the ability to significantly expand the market while improving outcomes based on more accurate electrophysiological mapping. ”

With this investment, Acutus Medical also announced it has recruited Graydon Beatty as its Chief Technology Officer. Graydon was previously an inventor of the EnSite Technology and founder of Endocardial Solutions, Inc., incorporated in 1992, which produced integrated advanced mapping and navigation systems for the location and improved treatment of cardiac arrhythmias.

Endocardial Solutions was acquired by St. Jude Medical, Inc. in 2005 where Graydon continued to contribute to product development.  Acutus President, Randy Werneth said, “With Graydon, we add a world-leading expert to our team of highly experienced and successful developers of advanced cardiac mapping and imaging systems. With his exceptional previous achievements and perfect fit with our team and our tasks we believe we are poised to produce a breakthrough in cardiac mapping systems.”

About Acutus Medical:
Acutus Medical is a medical technology company committed to developing an innovative breakthrough platform technology of safe, cost effective and clinically advanced tools for the minimally invasive diagnostic mapping of complex cardiac arrhythmias such as atrial fibrillation and ventricular tachycardia. The Company’s technology is being developed in the US and Europe and is expected to achieve CE marking within two years.  The company is located in San Diego, California and Zurich, Switzerland and is privately funded with lead investors, Index Ventures and Advent Ventures.

www.acutusmedical.com

About AdventLife Sciences:
Advent Life Sciences is the dedicated Life Sciences Fund at Advent Venture Partners, one of Europe’s best established growth and venture capital firms.  Advent Life Sciences invests predominantly in early-stage and growth equity life sciences companies in the UK, Europe and the US.  It will back companies that have a first- or best-in-class approach in a range of sectors within the life sciences, including new drug discovery, enabling technologies, med-tech and diagnostics.

The Advent Life Sciences team is a leader in European life sciences venture capital.  Its investments include:  PowderMed, a therapeutic DNA vaccine company sold to Pfizer; Thiakis, an obesity treatment company acquired by Wyeth Pharmaceuticals; Respivert, a drug discovery company focused on respiratory diseases that was acquired by Johnson & Johnson; EUSA Pharma, a rapidly growing transatlantic speciality pharmaceutical company focused on late-stage oncology, pain control and critical care products; and, Algeta (OSE: ALGETA), an oncology company developing treatments for bone metastases and disseminated tumours.

www.adventventures.com

For more information contact:

Acutus Medical
Randy Werneth, CEO
Email: randy.werneth@acutusmedical.com

Advent Venture Partners (London)
Josephine Defty
Ph: +44 (0) 20 7932 2116
Email: Josephine@adventventures.com

Advent Life Sciences Fund I welcomes additional investor

By Advent Life Sciences, Press Release
Press Release.

 

Présentation de deux projets de fonds d’investissement dans l’avenir de l’économie Luxembourgeoise

 

A l’issue d’une réunion conjointe de la commission parlementaire des Finances et du Budget et de la commission parlementaire de l’Economie, du Commerce extérieur et de l’Economie solidaire, le ministre des Finances, Luc Frieden, et le ministre de l’Économie et du Commerce extérieur, Jeannot Krecké, ont présenté deux projets de fonds d’investissement dans l’avenir de l’économie luxembourgeoise.

1.    Fonds Life Sciences

Le plan d’action « technologies de la santé » établi et présenté en 2007 prévoit la mise en place d’un outil de financement approprié. La décision du gouvernement d’investir à travers la Société Nationale de Crédit et d’Investissement (SNCI) dans un fonds capital à risque spécialisé dans le domaine des sciences biomédicales s’inscrit dans ce contexte.

Afin de s’assurer que l’investissement substantiel consenti par le gouvernement en matière de recherche biomédicale (en 2008 : 140 millions € étalés sur cinq ans) puisse sortir ses effets également d’un point de vue économique, le gouvernement a décidé de placer une somme à travers la SNCI dans un fonds d’investissement existant ayant fait ses preuves.

Suite à une procédure de sélection, c’est le groupe Advent Venture Partners de Londres qui a finalement été retenu. Advent Venture Partners a été créé en 1988 et le fonds Advent Life Sciences Fund I (ALSF I) dans lequel la SNCI investira une vingtaine de millions d’euro est le cinquième fonds mis en place par Advent. C’est leur premier fonds dédié exclusivement aux technologies biomédicales – les quatre autres fonds avaient deux axes d’investissement: les technologies de l’information et de la communication ainsi que les technologies de la santé. C’est un fonds d’investissement britannique libellé en livres sterling ayant une durée de vie de 10 ans pouvant être étendue deux fois d’une année. Par ailleurs, Le Fonds Européen d’Investissement (FEI) compte parmi les actionnaires d’ALSF I.

ALSF I a commencé à investir en février 2011 – à ce jour trois investissements sont réalisés. Le fonds vise une quinzaine d’investissements dont une dizaine environ sera consacré à la création de jeunes entreprises, et le reste au financement de projets. 70% des investissements seront réalisés en Europe.

Pour Raj Parekh, General Partner, Advent Life Sciences,

“cette initiative du gouvernement luxembourgeois dans le domaine des technologies de la santé est exceptionnelle aussi bien pour sa vision et que pour sa conception, et permet d’accélérer le développement du Luxembourg afin de devenir un acteur important dans les biotechnologies. C’est un privilège pour Advent Life Sciences d’avoir été choisi par le gouvernement et ses partenaires afin de les soutenir dans cette initiative importante.”

 

Les objectifs poursuivis par le gouvernement avec cet investissement sont multiples:

(a)    Participer à des investissements dans des projets porteurs et rémunérateurs, quelle que soit leur localisation géographique. Cette ouverture doit permettre:

•   d’intégrer le réseau des fonds en capital à risque et, partant, de faire connaître le Luxembourg;

•   d’investir dans des sociétés stratégiquement intéressantes pour l’effort de recherche consenti au niveau national.

(b)    Investir dans l’une ou l’autre société pouvant être implantée au Luxembourg dans un but de diversification économique.

(c)    Essaimer  l’un ou l’autre projet de valorisation issu de l’effort de recherche luxembourgeois si l’opportunité se présente

(d)    Assister  à la mise en place d’un dispositif de transfert de technologie en étroite coopération avec le gouvernement et les autres acteurs du terrain

(e)    Assurer un transfert de savoir vers les acteurs luxembourgeois et accroître la visibilité du Luxembourg en matière de sciences de la vie. A cet effet, Advent s’est notamment engagé à:

•    Assurer une présence au Luxembourg
•    Former l’un ou l’autre analyste  de l’administration gouvernementale
•    Organiser des réunions et conférences spécialisées au Luxembourg.

Au sujet d’Advent Life Sciences:

Advent Life Sciences est le fonds dédié aux sciences de la vie au sein d’Advent Venture Partners(www.adventventures.com), une des entreprises en capital risque les plus connues en Europe. Advent Life Sciences investit principalement dans des jeunes entreprises du secteur des technologies et sciences de la santé au Royaume-Uni, en Europe et aux Etats-Unis. Le fonds soutient des entreprises classées parmi les meilleures dans plusieurs domaines relatifs aux sciences de la vie, dont la découverte de nouvelles molécules, les technologies habilitantes, les technologies médicales et le diagnostic.

L’équipe d’Advent Life Sciences est leader en Europe en matière de capital risque dans le domaine des sciences de la vie. Parmi ses investissements, on trouve: PowderMed, une société ayant développé un vaccin thérapeutique ADN vendue à Pfizer; Thiakis, une société ayant développé un traitement contre l’obésité acquise par Wyeth Pharmaceuticals; Respivert, une société active dans le domaine des maladies respiratoires qui a été achetée par Johnson & Johnson; EUSA Pharma, une société pharmaceutique transatlantique active dans plusieurs segments dont le traitement du cancer en stade terminal et les antidouleurs; et, Algeta (OSE: ALGETA),une société active dans l’oncologie qui développe des traitements contre les métastases osseuses et les tumeurs disséminées.

2.    Luxembourg Future Fund

A la demande du Gouvernement, la SNCI, ensemble avec le Fonds Européen d’Investissement (FEI), mettra en place un Luxembourg Future Fund.

Ce fonds aura comme objet de soutenir la diversification et le développement durables de l’économie luxembourgeoise en contribuant à attirer au Luxembourg, directement ou indirectement, des activités entrepreneuriales en phase de démarrage/développement/croissance ou des activités contribuant à l’innovation.

Luxembourg Future Fund sera géré par le FEI qui y participera également en tant qu’investisseur minoritaire. Le FEI est spécialisé dans le financement à risque des PME en Europe et est majoritairement détenu  par la Banque Européenne d’Investissement. Avec actuellement plus que 12 milliards d’euros sous gestion, le FEI dispose d’une grande expérience et d’une excellente réputation  dans le domaine du capital à risque pour les PME.

Taille et investisseurs du Luxembourg Future Fund

La taille visée du fonds s’élèvera à quelque 150 millions d’euros. Le FEI participera en tant qu’investisseur avec 30 millions d’euros. La SNCI prend une participation à hauteur de 120 millions d’euros.

Gestionnaire du Luxembourg Future Fund

Le FEI sera chargé de la gestion du fonds. Il recourra aux compétences internes de ses départements en vue de la sélection, de l’analyse et du suivi des dossiers investis. Luxembourg Future Fund devra fonctionner suivant les règles de gouvernance du FEI.

Ce fonds pourra pleinement profiter non-seulement des structures et du savoir-faire du FEI pour la mise en place et la gestion, mais aussi de son expérience et de sa réputation pour le choix des projets à investir, le cas échéant aussi avec des co-investisseurs.

Stratégie d’investissement du Luxembourg Future Fund et nouvel instrument de diversification et de développement durables de l’économie luxembourgeoise

Deux grands principes cumulatifs de gestion régiraient le Fonds Luxembourgeois :

i.    Rentabilité financière : Le fonds sera géré et investira selon des critères strictement commerciaux avec des objectifs de performance financière bien définis à l’avance et en accord avec le profil de risque du fonds.

ii.    Retombées pour l’économie luxembourgeoise : Les investissements du fonds devront avoir une dimension permettant de s’attendre à avoir un impact en termes de diversification et de développement durables de l’économie luxembourgeoise.

Le Luxembourg Future Fund réalisera des investissements directs et indirects, ces derniers via une activité fond de fonds, dans des PME innovantes en phase de démarrage, de développement ou de croissance, actives dans les secteurs technologiques les plus variés (ICT, Cleantech et autres, à l’exclusion, directe et indirecte, du secteur des Technologies de la Santé/Life sciences) et contribuera indirectement au développement d’un écosystème en capital-risque au Luxembourg.

Les investissements seront réalisés dans des conditions pari-passu avec les co- investisseurs potentiels des projets investis tout en respectant les critères de rentabilité financière du fonds.

L’environnement luxembourgeois existant, avec ses  infrastructures (ICT, logistique) et son cadre fiscal (loi sur la propriété intellectuelle) viendra soutenir les efforts entrepris dans ce contexte pour favoriser le développement économique et la diversification du Luxembourg.

Les domaines d’investissement du Fonds Luxembourgeois

Luxembourg Future Fund investira soit directement soit indirectement à travers des fonds de fonds à capital risque, le cas échéant avec d’autres co-investisseurs.

Un nouvel instrument de diversification et de développement durables

II est entendu que le mode de fonctionnement est tel que l’Etat et la SNCI ou d’autres vont pouvoir contribuer au deal-flow en signalant au gestionnaire des projets potentiellement éligibles. Partant, Luxembourg Future Fund constituera un nouvel instrument complémentaire et d’importance de la politique de diversification et de développement durables de l’économie luxembourgeoise.

Le Luxembourg Future Fund devra décider d’une liste en principe négative des investissements ne remplissant pas les critères de responsabilité éthique, sociale ou environnementale.

Structure légale du Luxembourg Future Fund

Le FEI a une préférence pour un fonds fermé sous la forme d’un Fonds d’Investissement Spécialisé – SIF SICAV S.A. Il s’agit d’une structure de fonds qui doit obtenir l’agrément de la CSSF et qui fonctionne sous la surveillance de cette dernière.

Durée du fonds

Il est proposé que le fonds en question ait une durée de 15 ans qui peut être prolongée de maximum deux ans. Les investissements se feront sur les 5 premières années avec la possibilité d’augmenter la période d’investissement d’un an, sans toutefois exclure des réinvestissements ultérieurs des revenus générés par la cession d’actifs. Les parties devront s’engager à temps utile à discuter d’un fonds successeur (principe d’un fonds « evergreen »).

Gouvernance et reporting

Dans le cas d’une SICAV S.A., le Luxembourg Future Fund fonctionnera avec un Conseil d’administration, qui se composera de trois membres (deux membres seront désignés par la SNCI et un membre par le FEI) et une assemblée des actionnaires disposant des droits leur réservés par la loi et les statuts. Le Conseil sera informé des investissements du fond. Il lui incombera notamment d’assurer que tous les documents officiels requis soient préparés et transmis aux autorités de contrôles compétentes et que les assemblées des actionnaires soient préparées et tenues selon les règles de l’art.

Dans le cadre de la stratégie d’investissement arrêtée par les actionnaires, le FEI, en tant que gestionnaire du fonds, disposera d’un pouvoir de gestion indépendant (sélection, analyse et suivi des dossiers investis) qui lui sera délégué par le Conseil d’administration du Luxembourg Future Fund. Le FEI produira des rapports trimestriels sur le développement des investissements réalisés.

Un comité d’investissement sera créé (deux membres seront désignés par la SNCI et un membre par le FEI), qui disposera d’un droit de refus en ce qui concerne les décisions définitives d’investissement du fonds, identifiées et proposées par le gestionnaire, notamment afin de vérifier le respect de la condition concernant les retombées luxembourgeoises. Il est prévu que le comité d’investissement disposera aussi d’un droit de regard au niveau du suivi des projets et des désinvestissements.

Closing et démarrage des activités

Bien que le closing du fonds soit prévu pour le 1er semestre 2012, il est proposé que d’autres investisseurs stratégiques, qui adhèreraient aux objectifs et à la stratégie d’investissement du Luxembourg Future Fund et seraient prêts à s’engager pour une participation substantielle d’au moins 50 millions d’euros, pourraient rejoindre le fonds pendant les 12 mois suivant le closing. Chaque nouvel investisseur devrait être approuvé par les deux investisseurs fondateurs (FEI et SNCI). Il est prévu que la SNCI reste, dans
toutes les circonstances, majoritaire au niveau des droits de vote et du capital social.

Communiqué par le ministère des Finances et par le ministère de l’Économie et du Commerce extérieur

Final close of Advent Life Sciences

By Advent Life Sciences, Press Release
Press Release.

 

London, 24 November 2010: Advent Venture Partners today announced the final close of a $120M (£75M) venture capital fund, to be called Advent Life Sciences. The fund will be managed by General Partners Shahzad Malik and Raj Parekh, and is the first life sciences-focused fund raised by the firm.

The fund will invest predominantly in early- and mid-stage life sciences companies in the UK, Europe and the US. Advent Life Sciences will back companies that have a first- or best-in-class approach in a range of sectors within life sciences, including new drug discovery, enabling technologies, med tech and diagnostics.

Commenting on this close, Raj Parekh said,

“We are pleased to have closed our first life sciences fund at this level in an environment of unprecedented difficulty for raising European venture funds. We appreciate the support that our LPs have shown to the team and the sector, and we look forward to investing this fund at such an opportune time in the cycle.”

The fund was raised with the participation of the UK Future Technologies Fund, managed by the European Investment Fund, which invests in a range of technologies such as life sciences, digital technology, and advanced manufacturing.

Advent’s life sciences team has a first-class investment track record. Recent investments include Avila Therapeutics, Biocartis, Cellnovo, Respivert, Thiakis, Algeta and Amsterdam Molecular Therapeutics in all of which the Advent Life Sciences team led the formation of the Company and/or participated in the first venture round.

Advent Venture Partners announces the appointment of Dr Richard Mason to the Life Sciences team as Executive-in-Residence

By Advent Life Sciences, Press Release
Press Release.

 

London, 1 May 2007 – Advent Venture Partners (“Advent Ventures”) today announces the appointment of Dr Richard Mason as Executive-in-Residence. Richard will provide expertise, experience and leadership skills to key companies in the Advent Ventures portfolio.

Richard joins Advent Ventures from Cambridge Antibody Technology plc (‘CAT’) where he was Senior Vice President, Business Development and Commercial Operations. During his time at CAT, Richard led multiple transactions, including the negotiation of CAT’s joint antibody discovery and development collaboration with AstraZeneca. Since 2005, he also chaired the R&D team responsible for CAT’s establishment of a therapeutic focus in oncology and the subsequent in-licensing of a number of antibody product candidates.

Prior to joining CAT, Richard co-founded the e-health company, Cambridge Health Informatics Limited, having previously gained an MBA from the University of Cambridge. Richard graduated in Medicine from the Medical School of St Bartholomew’s Hospital and also holds a degree in Immunology from University College London. He is a qualified physician and before entering the business world he worked for 5 years for the NHS in internal medicine.

Commenting on this appointment, Dr Raj Parekh, Advent Ventures General Partner, said

“We are delighted to have Richard join the team as part of our plan to add resources and skills to help our portfolio companies succeed. His outstanding track record in business development will be a major asset for many of our portfolio companies”

For more information please contact:

Dr Raj Parekh/Dr Richard Mason, Advent Venture Partners, 020 7932 2100

Shona Prendergast / Francesca Reville,

Penrose Financial, 020 7786 4884 / 4811

 

About Advent Venture Partners – Advent Ventures is one of the most experienced technology venture capital firms in the UK. Established in 1981 it invests in both the Life Science and the Technology sectors. Advent Ventures has over £500 million (US$ 900m) under management from institutional investors across Europe and the USA. It has backed around 60 life science companies of which, to date, 21 have obtained public listings and a further 9 companies have been sold including PowderMed (to Pfizer) and KuDOS Pharmaceuticals (to AstraZeneca). Recent investments by the Advent Life Sciences team include Norwegian radiopharmaceuticals company, Algeta; the US speciality pharma company, CardioKine Inc; the US medical device company NeoGuide, UK-based Thiakis which develops hormone-based treatments for obesity, the Swiss therapeutic antibody company, 4-Antibody and EUSA Pharma Inc, a new transatlanticspecialtypharmaceutical company.

PRINCETON, New Jersey, December 19, 2022 – F2G Inc. today announced that the U.S. Food and Drug Administration (FDA) has accepted for filing its New Drug Application (NDA) for olorofim for the treatment of invasive fungal infections in patients who have limited or no treatment options.

F2G has requested approval of the NDA under the Limited Population Pathway for Antibacterial and Antifungal Drugs (LPAD pathway) for a limited, well-defined population with invasive fungal infections and limited or no treatment options. Under the Prescription Drug User Fee Act (PDUFA), the FDA has set a target action date of June 17, 2023

The NDA is supported by strong efficacy data and a good tolerability profile seen during treatment of the first 100 patients in the Phase 2b open-label study, all of whom had limited or no treatment options for either proven invasive fungal infection (including aspergilllosis, lomentosporiosis, scedosporiosis, Scopulariopsis infections, and refractory extrapulmonary coccidioidomycosis) or probable pulmonary invasive aspergillosis (Study 32, NCT03583164).

“Invasive fungal infections cause substantial morbidity and mortality, particularly among immunosuppressed patients, and can prove to be lethal in also healthy individuals when they get into deeper tissues. Effective therapies do not currently exist for some of these fungi. And even when therapies exist, some patients with invasive infections may be refractory or unable to tolerate existing antifungal treatments, thus underscoring the urgent need for new and effective treatments,” said John H. Rex, MD, chief medical officer of F2G. “Olorofim is a novel mechanism antifungal therapy from the newly discovered orotomide class. It provides a new option for patients who have exhausted treatment alternatives.”

Francesco Maria Lavino, chief executive officer of F2G, added,

“We are committed to addressing rare fungal infections, and the acceptance of filing of olorofim NDA for use in this well-defined and high-need population marks a major milestone toward our goal of bringing new options to these patients. We are building an experienced commercial team in preparation for U.S. launch, pending FDA approval. If approved, olorofim will be the first of a new class of antifungal drugs.”

Olorofim is the only antifungal medication to be awarded Breakthrough Therapy Designation by the FDA. Olorofim works through a novel mechanism of action, different from existing classes of antifungals, exerting fungal cell death through inhibition of the enzyme dihydroorotate dehydrogenase (DHODH) in the pyrimidine synthesis pathway. It is active in vitro against Aspergillus spp. (including azole-resistant and cryptic species), rare molds (e.g., Lomentospora prolificans, Scedosporium spp., Scopulariopsis spp.), and dimorphic fungi (e.g., Coccidioides spp.).

About Olorofim

Olorofim (formerly, F901318) is F2G’s leading candidate from the orotomide class and is currently being investigated in a Phase 2b open-label study in patients who have limited treatment options for difficult-to-treat invasive, rare fungal mold infections such as azole-resistant aspergillosis, scedosporiosis, lomentosporiosis, and other rare mold infections. F2G has initiated a global Phase 3 trial (“OASIS”) to compare treatment with olorofim versus AmBisome® followed by standard of care (SOC) in patients with proven or probable invasive fungal infection due to Aspergillus species (NCT05101187). Olorofim has received orphan drug designation from the FDA for the treatment of coccidioidomycosis, scedosporiosis (including lomentosporiosis), invasive Scopulariopsis, and invasive aspergillosis. Olorofim has also received orphan drug designation from the European Medicines Agency (EMA) for the treatment of invasive aspergillosis, invasive scedosporiosis (including lomentosporiosis), and invasive Scopulariopsis. Olorofim has been granted Qualified Infectious Disease Product (QIDP) designation for invasive aspergillosis, invasive scedosporiosis, invasive lomentosporiosis, coccidioidomycosis, invasive disease due to Scopulariopsis species, and invasive fusariosis. Olorofim has received Breakthrough Therapy Designation for both “treatment of invasive mold infections in patients with limited or no treatment options, including aspergillosis refractory or intolerant to currently available therapy, and infections due to Lomentospora prolificans, Scedosporium, and Scopulariopsis species” and “treatment of Central Nervous System (CNS) coccidioidomycosis refractory or otherwise unable to be treated with standard of care therapy.” Olorofim is not approved by the FDA or any other regulatory agency.

About F2G

F2G is a biotech company with operations in the UK, US, and Austria focused on the discovery and development of novel therapies to treat potentially life-threatening invasive fungal infections. F2G has discovered and developed a completely new class of antifungal agents called the orotomides which selectively target a key enzyme in the de novo pyrimidine biosynthesis pathway. This is a completely different mechanism from that of the currently marketed antifungal agents and gives the orotomides fungicidal activity against a broad range of rare and resistant fungal mold infections. For more information, please visit: www.f2g.com

Forward-Looking Statements

This announcement contains forward-looking statements. These statements are based on expectations in light of the information currently available, assumptions that are subject to risks and uncertainties which could cause actual results to differ materially from these statements. Risks and uncertainties include general domestic and international economic conditions such as general industry and market conditions, and changes of interest rate and currency exchange rate. These risks and uncertainties particularly apply with respect to product-related forward-looking statements. Product risks and uncertainties include, but are not limited to, completion and discontinuation of clinical trials; obtaining regulatory approvals; claims and concerns about product safety and efficacy; technological advances; adverse outcome of important litigation; domestic and foreign healthcare reforms and changes of laws and regulations. Also, for existing products, there are manufacturing and marketing risks, which include, but are not limited to, inability to build production capacity to meet demand, lack of availability of raw materials and entry of competitive products. The company disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise.

Media Contact:

Gloria Gasaatura
LifeSci Communications
+1 646 970 4688
ggasaatura@lifescicomms.com